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Dongying Rich Chemical Co.,Ltd

Acetyl Aniline Experimental Method

Preparation of acetanilide and identification of infrared spectroscopy First, the experimental purpose 

1. To master the principle of aniline acetylation reaction and experimental operation. 2. Study the method of solidification of solid organic matter - recrystallization. 3, to understand the infrared spectroscopy method of identification of organic compounds. Second, the experimental principle 1, aniline acetylation of amine acylation in organic synthesis has an important ...

Preparation of acetanilide 1, the purpose of the experiment 

1.Acetyl Aniline Understanding the principle and operation of fractional distillation; 2.Acetyl Aniline Master the aniline acetylation reaction principle and operation; 3. Learn to master the solid compound recrystallization purification principles and methods. Second, the experimental principle  aromatic primary amine aromatic ring and amino groups are easy to react, in the organic synthesis in order to protect the amino, often first B ...

Acetanilide preparation, purification and structural analysis First, the experimental purpose 1, familiar with the principle and significance of amino acylation reaction, master the preparation of acetanilide. 2, learning the principle and technology of fractional distillation. 3, master grasp the recrystallization, hot filter and decompression filtration and other operating techniques. 4, to understand the infrared spectroscopy identification of organic compounds structure and methods.

Acetyl Aniline experiment one

First, the experimental purpose of the preparation of acetanilide

⑴ familiar with the principle and significance of amino acylation reaction, master the preparation of acetanilide;

⑵ to further grasp the installation and operation of fractional distillation device;

⑶ master grasp the recrystallization, hot filter and decompression filtration and other operating techniques.

Second, the experimental principle

Acetyl Aniline Use of acetanilide:

Acetanilide, white shiny flaky crystalline or white crystalline powder, is the raw material of sulfonamides, can be used as analgesics, antipyretic agents (commonly known as "hot ice"), preservatives and dye intermediates. Stability: stable in the air, case of acid or alkaline aqueous solution easily decomposed into aniline and acetic acid. As the aromatic ring on the amino oxidation, in organic synthesis in order to protect the amino, often first of its acetylation into acetanilide, and then other reactions, the final hydrolysis to remove acetyl. The need for aniline acetylation:

(1) As a protective measure, primary and secondary aromatic amines (i.e., primary and secondary amines) are converted into their acetyl derivatives in synthesis to reduce the sensitivity of the aromatic amine to the oxidizing agent so that it is not Reaction reagent Acetyl Aniline failure;

(2) After the acylation of the amino group, the activation ability of the amino group in the electrophilic substitution reaction (particularly halogenation) is reduced, making it a strong first class I locus into a medium-intensity type I localization, Substituted substitutes for useful substitutes;

(3) the selective substitution of the para-substituted product due to the spatial effect of the acetyl group;

(4) In some cases, acylation can avoid amino groups with other functional groups or reagents


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